High density lipoprotein/sphingosine-1-phosphate-induced cardioprotection
نویسندگان
چکیده
منابع مشابه
High density lipoprotein/sphingosine-1-phosphate-induced cardioprotection
High density lipoprotein (HDL) cholesterol has beneficial effects beyond its atheroprotective function in reverse cholesterol transport, including cardioprotection against ischemia reperfusion (IR) injuries. Two major constituents of HDL, namely the structural protein apolipoprotein AI (apoAI) and the sphingolipid sphingosine-1-phosphate (S1P) appear to contribute to this cardioprotective effec...
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Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein (HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate (S1P) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, an...
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The onset of coronary occlusion caused by vasospasm, thrombosis, or atherosclerotic plaque rupture produces myocardial ischaemia, and acute myocardial infarction (AMI) can result within minutes. Reperfusion with minimal time lapse is the treatment of choice for AMI, but coronary reperfusion can also enhance myocardial injury and the induction of life-threatening cardiac arrhythmias. In 1986, it...
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Epidemiological studies strongly suggest an inverse correlation between plasma high-density lipoprotein (HDL) concentration and the risk of ischemic heart disease.1,2 Experimental evidence also exists to indicate cardioprotective effects of HDL.3 However, the mechanism for protective effect of HDL against ischemic heart disease is not completely understood. Although the widely accepted mechanis...
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The high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis...
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ژورنال
عنوان ژورنال: JAK-STAT
سال: 2012
ISSN: 2162-3996
DOI: 10.4161/jkst.19754